The Washington State University Catalog

School of Molecular Biosciences

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School of Molecular Biosciences

smb.wsu.edu
Biotechnology-Life Sciences 102
509-335-1276

Director and Professor, J. Jones; Senior Associate Director and Professor, M. Konkel; Associate Director for Graduate Program and Professor, K. Kim; Associate Director for Undergraduate Programs and Associate Professor, W. Davis; Associate Director for Alumni Relations and Clinical Associate Professor, M. Sanchez-Lanier; Director of PSM Program, Associate Director of Online Courses, and Clinical Associate Professor, N. McCabe; Assistant Director for Undergraduate Laboratories and Clinical Associate Professor, C. Helmick; Regents Professors, M. Griswold, M. Smerdon; Professors, J. Alderete, M. Black, R. Brosemer, T. Hassold, P. Hunt, L. Xun; Associate Professors, R. Carabeo, C. Cooper (Vancouver), L. Gloss, C. Haseltine, C. Her, J. Oatley, E. Offerdahl, E. Shelden, S. Sylvester (Vancouver), S. Wang, J. Watts, J. Wyrick; Assistant Professors, R. Driskell, A. Goodman, S. Roberts, W. Winuthayanon; Clinical Assistant Professor , M. Rolfsmeier; Affiliate Faculty, H. Aguilar-Carreno, T. Bankhead, K. Brayton, W. Brown, J. Browse, D. Call, J. Celli, W. Chai (Spokane), M. Chandra, O. Cornejo, J. Harding, M. Hardy, M. Kahn, C. H. Kang, I. Karatsoreos, T. Kawula, J. Kelley, L. Knodler, M. Lange, A. Nicola, A. Omsland, J. Pru, K. Roberts (Spokane), B. Rodgers, B. Tanner, L. Thomashow, G. Trobridge, V. Vadyvaloo, B. Walker, G. Wayman, J. Xu; Clinical Associate Professor, P. Mixter; Clinical Assistant Professor, M. Rolfsmeier.

Molecular biosciences can be viewed as a dynamic continuum in which approaches derived from biology, chemistry, and physics are utilized to address the fundamental mechanisms of living things. The School of Molecular Biosciences (SMB) offers undergraduate majors in biochemistry, genetics and cell biology, and microbiology. The School of Molecular Biosciences also offers undergraduate minors in biochemistry, genetics and cell biology, microbiology, molecular biology, and pre-genetic counseling. Requirements for these majors and minors are detailed below.

At the graduate level, the school offers programs leading to the degrees of Master of Science and Doctor of Philosophy in Molecular Biosciences. The School also offers a Professional Science Master's degree in Molecular Biosciences that can be earned either on the Pullman Campus or through WSU Global Campus. In addition the school offers a combined undergraduate degree in Genetics and Cell Biology and PSM in Molecular Biosciences.

At the undergraduate level, we expect that our graduating students will possess: 1) an understanding of the major concepts in the molecular biosciences and an awareness of how these concepts are integrated from the molecular to the organismal level; 2) the necessary critical thinking and quantitative reasoning skills, and the ability to apply those skills, to identify and solve biological problems at the cellular, molecular, and structural levels; 3) the oral and written communication skills necessary to effectively communicate key scientific findings in the molecular biosciences to both non-scientific and professional audiences; 4) the scientific literacy necessary to become an informed citizen of a diverse, ever changing, global society, and to engage in a lifetime of scientific learning; and 5) the relevant ethics education and exposure necessary to encourage the highest levels of professionalism and humanism.

STUDENTS PURSUING PRE-MEDICINE, PRE-DENTAL, PRE-PHARMACY, PRE-PHYSICIAN ASSISTANT OR PRE-VETERINARY MEDICINE

The majors in the School of Molecular Biosciences provide a perfect home for the student who is interested in pursuing professional education after graduating from WSU. Our degrees have been designed to prepare students to succeed in these professional programs, as well as on the latest versions of the standardized examinations for admission to professional programs. Pre-professional students majoring in SMB are advised by a faculty member in the School and additionally work with a professional specialist from the Health Professions Student Center.

Students from all three SMB undergraduate majors have been successfully admitted to professional programs in human medicine, veterinary medicine, physician assistant, pharmacy, and dentistry. The Biochemistry degree is a perfect match for pre-pharmacy students and highly motivated students should consider our 7-year Fast track B.S. Biochemistry-PharmD program offered in cooperation with the WSU School of Pharmacy. Pre-veterinary medicine students can elect to pursue any SMB major, and high-achieving students should consider the 7-year Honors Fast track B.S. Microbiology to DVM program.  Students interested in either of these fast track programs should contact the School for more information.

BIOCHEMISTRY

Biochemistry is an interdisciplinary science that applies the methods and theories of chemistry to understand chemical reactions in living organisms. Biochemists seek to understand life at all levels, from individual molecules inside cells to complex interactions within ecosystems.  An undergraduate major in biochemistry will prepare you for a variety of careers including biotechnology, drug design, science policy, bioinformatics, forensics, genetic counseling, health professions, science communication, and so many more!  Biochemistry majors will be able to apply the principles of biochemistry, biophysics, and molecular biology to answer questions in a wide range of research areas including protein biochemistry, molecular biology of gene regulation, enzymatic reaction mechanisms, signal transduction, DNA repair, reproductive biology, DNA-protein interactions, plant and natural product biochemistry, and structural biology including nuclear magnetic resonance (NMR) spectroscopy and x-ray crystallography.

The program offers two curricular options leading to the Bachelor of Science in Biochemistry. The biochemistry/biophysics option provides increased emphasis on chemistry, physics, mathematics, and physical biochemistry, and yields a minor in chemistry. The biochemistry/molecular biology option provides increased emphasis on molecular and cell biology.

GENETICS AND CELL BIOLOGY

Genetics and cell biology are interrelated sciences that are fundamental to all fields of modern biology. Undergraduates who major in genetics and cell biology will be well versed in aspects of the rapidly emerging fields of genomics, epigenetics, proteomics, bioinformatics and molecular signaling. The program affords students the opportunity to learn from and interact with scientists whose diverse research programs include the genetics of cancer and development, chromosome abnormalities, DNA repair mechanisms, stem cell biology and the biology of reproduction.  Our faculty work with a diverse group of model organisms including C. elegans, Drosophila, zebrafish, mice and rats, as well as using cell culture, plants, and microbial experimental systems.  Graduates of the degree will be prepared to work in careers that traditionally may not have required science training including: science communication, forensics, law enforcement, community outreach science organizations and science policy development.  In addition, students will be trained for positions as researchers in biotechnology companies, within healthcare and in academic institutions. This degree also prepares students for entry into graduate programs leading to Master's, Professional Science Master’s and PhD degrees in a variety of disciplines including the broad areas of molecular biology, molecular genetics and cell biology.  In addition, students will also be well prepared to enter the professions of medicine, dentistry, veterinary medicine, physician assistant, genetic counseling and education.

MICROBIOLOGY

Microbiology is both a basic and an applied science that studies microorganisms and their activities. It is concerned with their form, structure, reproduction, physiology, and identification. It includes the study of their distribution in nature, their relationship to each other and to other living things, their beneficial and detrimental effects on human beings, and the physical and chemical changes they make in their environment. Employment opportunities in industrial, government, hospital, and private laboratories and agencies are excellent for qualified graduates. Areas in which the unit is prepared to direct research include bioremediation, molecular genetics, molecular basis of cell-cell interactions and pathogen virulence, microbial differentiation, cellular immunology and the regulation of the immune response.

The Microbiology degree program offers options in either molecular biology or medical technology, leading to the Bachelor of Science degree in Microbiology. An additional year in an accredited school of clinical laboratory sciences is required after graduation for those interested in becoming certified clinical laboratory scientists.

CERTIFICATION REQUIREMENTS:

A student must meet the following three requirements to be eligible to certify as a SMB major in biochemistry, genetics and cell biology, or microbiology:

  • Complete BIOLOGY 106, BIOLOGY107, CHEM 105 and CHEM 106, or transfer equivalents, with a minimum grade of C.
  • Earn a minimum cumulative GPA of at least 2.50.
  • Earn a minimum of 24 semester hours.

Students must maintain a minimum cumulative GPA of 2.50 for all WSU courses to remain certified in a SMB degree program. A certified major who falls below the minimum requirements will be decertified according to Academic Regulation 56.

GRADUATION REQUIREMENTS:

A grade of C or better is required in all MBIOS courses taken to meet graduation requirements. None of these courses may be taken pass/fail.

STUDENT LEARNING OUTCOMES

For the Biochemistry, Genetics and Cell Biology, and Microbiology Degree Programs:  

 Before Graduating with a degree from SMB, a student will achieve these learning outcomes:

    (Global)

  1. Be competitive for professional and graduate studies and/or employment.

    (Knowledge)

  2. Identify the modern foundational knowledge underlying Biochemistry, Cell Biology, Genetics, and Microbiology. 
  3. Recognize relevant ethical concepts related to scientific publication and research conduct.

    (Skills)

  4. Perform basic laboratory techniques used in molecular bioscience research (e.g. light microscopy, gel electrophoresis, PCR, and protein analysis).
  5. Design, perform, and quantitatively/qualitatively evaluate the results of laboratory experiments.
  6. Locate, retrieve, and evaluate scientific information, especially primary literature, with regards to its adequacy, value, and logic.
  7. Prepare oral and written reports in standard scientific formats.

    (Attitudes)

  8. Decide that studying the molecular biosciences is rewarding and relevant to everyday life experiences.
  9. Appreciate the importance of the ethical implications of scientific issues in society.

 

Schedules of Studies

Honors students complete the Honors College requirements which replace the UCORE requirements.

Biochemistry - Biophysics Option(120 Hours)

A grade of C or better is required in all MBIOS courses taken to meet graduation requirements. None of these courses may be taken pass/fail.

First Year
First TermHours
BIOLOGY 106 [BSCI] or 107 [BSCI]4
CHEM 105 [PSCI]4
ENGLISH 101 [WRTG]3
MATH 106 (accelerated) or Elective13
MATH 108 (accelerated) or Elective12
Second TermHours
BIOLOGY 106 or 1074
CHEM 1064
HISTORY 105 [ROOT]3
MATH 171 [QUAN]4
Second Year
First TermHours
CHEM 3454
Communication [COMM] or Written Communication [WRTG]3
MATH 1724
MBIOS 3014
Second TermHours
CHEM 3484
MBIOS 3034
PHYSICS 2014
Social Sciences [SSCI]3
Complete Writing Portfolio
Third Year
First TermHours
Creative & Professional Arts [ARTS]3
Humanities [HUM]3
PHYSICS 2024
MBIOS 3053
Second TermHours
CHEM 3473
Diversity [DIVR]3
MBIOS 3043
MBIOS 4013
MBIOS 4653
Fourth Year
First TermHours
CHEM 2202
CHEM 2222
MBIOS 413 3
MBIOS 466 or PHYSICS 4663
Electives3
Second TermHours
Lab Elective23
MBIOS 4143
MBIOS 454 [M]3
MBIOS 494 [M] [CAPS]3
Electives6
Exit Survey

Footnotes

1If required - consult advisor.
2Lab Elective: minimum of 3 credits selected from MBIOS 402, 411, 430, 498, 499; BIOLOGY 251, 315, 353.

Biochemistry - Molecular Biology Option(120 Hours)

A grade of C or better is required in all MBIOS courses taken to meet graduation requirements. None of these courses may be taken pass/fail.
First Year
First TermHours
BIOLOGY 106 [BSCI] or 107 [BSCI]4
CHEM 105 [PSCI]4
ENGLISH 101 [WRTG] or Elective3
MATH 106 (accelerated) or Elective13
MATH 108 (accelerated) or Elective12
Second TermHours
BIOLOGY 106 or 1074
CHEM 1064
HISTORY 105 [ROOT]3
MATH 140 [QUAN] or 171 [QUAN]4
Second Year
First TermHours
CHEM 3454
Communication [COMM] or Written Communication [WRTG]3
MBIOS 3014
PHYSICS 101 or 2014
Second TermHours
CHEM 3484
MBIOS 3034
PHYSICS 102 or 2024
Social Sciences [SSCI]3
Complete Writing Portfolio
Third Year
First TermHours
Creative & Professional Arts [ARTS]3
Humanities [HUM]3
MBIOS 3053
STAT 212 or 4123 or 4
Electives3
Second TermHours
Diversity [DIVR]3
MBIOS 304 3
MBIOS 4013
MBIOS 4653
Electives3
Fourth Year
First TermHours
Lab Elective23 or 4
MBIOS 4043
MBIOS 4133
Electives5
Second TermHours
MBIOS 4143
MBIOS 454 [M]3
MBIOS 494 [M] [CAPS]3
Lecture Elective33
Electives3
Exit Survey

Footnotes

1If required - consult advisor.
2Lab Elective: minimum of 3 credits from MBIOS 402, 411, 430, 498, 499; BIOLOGY 251, 315, 353.
3Lecture elective: select one from MBIOS 410, 423, 426, 440, 442, 450, 466, 478; PHYSICS 466.

Genetics and Cell Biology – Molecular Biology Option(120 Hours)

A grade of C or better is required in all MBIOS courses taken to meet graduation requirements. None of these courses may be taken pass/fail. Completed core requirements may not be used to satisfy lecture or lab electives.
First Year
First TermHours
BIOLOGY 106 [BSCI] or 107 [BSCI]4
CHEM 105 [PSCI]4
ENGLISH 101 [WRTG]3
MATH 106 (accelerated) or Elective13
MATH 108 (accelerated) or Elective12
Second TermHours
BIOLOGY 106 or 1074
CHEM 1064
HISTORY 105 [ROOT]3
MATH 140 [QUAN] or 171 [QUAN]4
Second Year
First TermHours
CHEM 34524
Humanities [HUM]3
MBIOS 3014
PHYSICS 101 or 2014
Second TermHours
Creative & Professional Arts [ARTS]3
MBIOS 3034
PHYSICS 102 or 2024
Social Sciences [SSCI]3
Complete Writing Portfolio
Third Year
First TermHours
Communication [COMM] or Written Communication [WRTG]3
MBIOS 3043
MBIOS 3053
STAT 212 or 4123 or 4
Electives3
Second TermHours
Diversity [DIVR]3
Lecture Elective33
MBIOS 4013
Electives4
Fourth Year
First TermHours
Lab Elective43 or 4
MBIOS 4043
MBIOS 4233
MBIOS 4783
Electives3
Second TermHours
MBIOS 402 [M]3
MBIOS 442 or BIOLOGY 4763
MBIOS 494 [M] [CAPS]3
Electives8
Exit Survey

Footnotes

1If required - consult advisor.
2CHEM 345 and 348 recommended for professional or graduate degrees.
3Lecture elective: select one from BIOLOGY 420, 475, 476; MBIOS 410, 413, 426, 440, 442, 450, 503.
4Lab Elective: minimum of 3 credits selected from MBIOS 411, 430, 454, 498, 499; BIOLOGY 251, 315, 321, 353, 372.

Microbiology – Medical Technology Option(120 Hours)

A grade of C or better is required in all MBIOS courses taken to meet graduation requirements. None of these courses may be taken pass/fail.

Completed core requirements may not be used to satisfy lecture or lab electives.
First Year
First TermHours
BIOLOGY 106 [BSCI] or 107 [BSCI]4
CHEM 105 [PSCI]4
ENGLISH 101 [WRTG]3
MATH 106 (accelerated) or Elective13
MATH 108 (accelerated) or Elective12
Second TermHours
BIOLOGY 106 or 1074
CHEM 1064
HISTORY 105 [ROOT]3
MATH 140 [QUAN] or 171 [QUAN]4
Second Year
First TermHours
CHEM 34524
Creative & Professional Arts [ARTS]3
Humanities [HUM]3
MBIOS 3014
Second TermHours
MBIOS 3034
MBIOS 3053
Social Sciences [SSCI]3
Electives3
Complete Writing Portfolio
Third Year
First TermHours
Communication [COMM] or Written Communication [WRTG]3
MBIOS 3043
PHYSICS 101 or 2014
STAT 212 or 4123 or 4
Electives3
Second TermHours
Diversity [DIVR]3
MBIOS 4103
MBIOS 4503
PHYSICS 102 or 2024
Electives3
Fourth Year
First TermHours
BIOLOGY 4184
MBIOS 4043
MBIOS 430 [M]3
MBIOS 4403
Electives3
Second TermHours
MBIOS 411 [M]3
MBIOS 4423
MBIOS 494 [M] [CAPS]3
Electives5
Exit Survey

Footnotes

1If required - consult advisor.
2CHEM 345 and 348 recommended for professional or graduate degrees.

Microbiology – Molecular Biology Option(120 Hours)

A grade of C or better is required in all MBIOS courses taken to meet graduation requirements. None of these courses may be taken pass/fail.

Completed core requirements may not be used to satisfy lecture or lab electives.
First Year
First TermHours
BIOLOGY 106 [BSCI] or 107 [BSCI]4
CHEM 105 [PSCI]4
ENGLISH 101 [WRTG]3
MATH 106 (accelerated) or Elective13
MATH 108 (accelerated) or Elective12
Second TermHours
BIOLOGY 106 or 1074
CHEM 1064
HISTORY 105 [ROOT]3
MATH 140 [QUAN] or 171 [QUAN]4
Second Year
First TermHours
CHEM 34524
Creative & Professional Arts [ARTS]3
Humanities [HUM]3
MBIOS 3014
Second TermHours
MBIOS 3034
MBIOS 3053
Social Sciences [SSCI]3
Electives4
Complete Writing Portfolio
Third Year
First TermHours
Communication [COMM] or Written Communication [WRTG]3
MBIOS 3043
PHYSICS 101 or 2014
STAT 212 or 4123 or 4
Electives2
Second TermHours
Diversity [DIVR]3
MBIOS 4103
MBIOS 4503
PHYSICS 102 or 2024
Electives3
Fourth Year
First TermHours
Lecture Elective33
MBIOS 4043
MBIOS 430 [M] or 411 [M]3
MBIOS 4403
Electives3
Second TermHours
Lab Elective43 or 4
MBIOS 4423
MBIOS 494 [M] [CAPS]3
Electives6
Exit Survey

Footnotes

1If required - consult advisor.
2CHEM 345 and 348 recommended for professional or graduate degrees.
3Lecture elective: select one from MBIOS 342, 401, 413, 426, 446; BIOLOGY 418, ENTOM 343, FS 416.
4Lab Elective: minimum of 3 credits selected from MBIOS 402, 411 or 430, 454, 498, 499; BIOLOGY 251, 315, 353; ENTOM 344; FS 417.

Minors

Biochemistry

A minor in biochemistry requires 17 hours including CHEM 348; MBIOS 303, 304, 413; MBIOS 414, 465, or CHEM 331. A grade of C or better is required in all courses used in the minor. None of these courses may be taken pass/fail.  Credit hours for the minor must include 9 hours of upper-division work taken in residence at WSU or through WSU-approved education abroad or educational exchange courses.

Genetics and Cell Biology

A minor in genetics and cell biology requires 16 hours under the genetics and cell biology degree program at the 300-400-level, including MBIOS 301, 401, and 423. Additional credits may be selected from BIOLOGY 321, MBIOS 402, 404, 426, 478, PHIL 365.  9 hours of upper-division work must be taken in residence at WSU or through WSU-approved education abroad or educational exchange courses.  A grade of C or better is required in all course work for the minor.

Microbiology

A minor in microbiology requires a minimum of 16 credit hours including MBIOS 305, 304 or 306, and the remaining selected from: MBIOS 342, 404, 410, 411, 426, 430, 440, 442, 446, 450, 548, FS 416.  9 hours of upper-division work must be taken in residence at WSU or through WSU-approved education abroad or educational exchange courses.  A grade of C or better is required in all course work for the minor.

Molecular Biology

A minor in molecular biology requires 20 hours including the following courses: MBIOS 301, 305, 303, 304; MBIOS 401 or 450; MBIOS 404, 413, or 440. A grade of C or better is required in all course work for the minor. Credit hours for the minor must include 9 hours of upper-division work taken in residence at WSU or through WSU-approved education abroad or educational exchange courses. A student whose major is in the School of Molecular Biosciences cannot be granted a minor in molecular biology.

Pre-Genetic Counseling

A minor in pre-genetic counseling requires 19 - 23 hours including MBIOS 301, 423, PHIL 365, PSYCH 321 or 333, 440 or 444, 445, one of MATH 360, PSYCH 311, STAT 212, or 412. A grade of C or better is required in all course work for the minor.  Credit hours for the minor must include 9 hours of upper-division work taken in residence at WSU or through WSU-approved education abroad or educational exchange courses.

Certificates

Molecular Biosciences

The Certificate in Molecular Biosciences requires a minimum of 18 hours.  Students are expected to have already completed courses equivalent to one year of freshman chemistry for science majors; one year of freshman biology for science majors; and one semester of organic chemistry; all through an accredited institution of higher education before working towards this certificate.  The 15 hour core is: MBIOS 101 or 305 and 306, or 304 and 305; MBIOS 301; MBIOS 303; and MBIOS 320.  3 hours of electives are selected from: ANTH 468, BIOLOGY 140, BIOLOGY 330, CRM J 320, MBIOS 342, PHIL 103, or 365.  A grade of C or better must be earned in all classes that apply towards this certificate.  Most of the courses required for this certificate have prerequisites.  Please consult the catalog to assure that these prerequisites have been met prior to registering for courses.

Courses

Molecular Biosciences (MBIOS)

101 [BSCI] Introductory Microbiology 4 (3-3) Course Prerequisite: Not intended for majors in the School of Molecular Biosciences. Microbiology for the informed citizen as it impacts humans and their environment. Not for students needing BIOLOGY 106 and 107. Typically offered Fall, Spring, and Summer.

138 Molecular Biosciences Seminar 1 Introduction to the field of molecular biosciences: careers, current events, research opportunities at WSU, scientific and research ethics. Typically offered Spring. S, F grading.

201 [COMM] Introduction to Communication in the Molecular Life Sciences 3 (1-4) Course Prerequisite: BIOLOGY 106 with a C or better or BIOLOGY 107 with a C or better. Analysis of primary literature and an introduction to scientific communication skills in the molecular life sciences. (Crosslisted course offered as NEUROSCI 201, MBIOS 201). Recommended preparation: Pre-certified or certified major in Biochemistry, Genetics & Cell Biology, Microbiology, or Neuroscience. Typically offered Spring.

210 Your Future in Life Sciences 2 Exploration of career options in biological sciences with faculty and outside speakers; guide to preparing resume and career plans. (Crosslisted course offered as SCIENCE 210, BIOLOGY 210, MBIOS 210). Typically offered Fall. S, F grading.

301 General Genetics 4 Course Prerequisite: BIOLOGY 106 or 120; BIOLOGY 107; CHEM 101 or 105; CHEM 102 or 106. Principles of modern and classical genetics. (Crosslisted course offered as MBIOS 301, BIOLOGY 301). Typically offered Fall, Spring, and Summer.

303 Introductory Biochemistry 4 Course Prerequisite: CHEM 102 or 345. Modern biochemistry for undergraduates in the biological sciences. Typically offered Fall, Spring, and Summer. Cooperative: Open to UI degree-seeking students.

304 Microbiology and Molecular Biology Laboratory 3 (1-6) Course Prerequisite: MBIOS 303 or concurrent enrollment, or MBIOS 305 or concurrent enrollment. Basic microbiology and molecular biology techniques. Typically offered Fall, Spring, and Summer.

305 General Microbiology 3 Course Prerequisite: BIOLOGY 107; CHEM 102 or 345. Structure, function, nutrition, physiology, and genetics of microbes and their application to immunology, pathology, microbial diversity, and environmental microbiology. Recommended preparation: MBIOS 303. Typically offered Fall, Spring, and Summer.

306 General Microbiology Laboratory 2 (0-6) Course Prerequisite: MBIOS 305 or concurrent enrollment. Laboratory for MBIOS 305.

320 [BSCI] DNA and Society 3 The role of DNA in natural processes and diseases; impact of biotechnology on health care, agriculture, industry, and our lives. Recommended preparation: One college-level course in biology highly recommended. Typically offered Fall and Spring.

342 Microbial Ecology 3 Course Prerequisite: BIOLOGY 106 or 120; CHEM 102 or concurrent enrollment, or CHEM 345 or concurrent enrollment. Discussion of microorganism behavior in nature and microbial activities influence on ecological balance. Typically offered Fall.

360 [M] Cell and Molecular Laboratory 2 (0-6) Course Prerequisite: MBIOS 301; MBIOS 303 or concurrent enrollment. Laboratory methods in cell biology, genetics and molecular biology. Typically offered Spring.

401 Cell Biology 3 Course Prerequisite: MBIOS 301; MBIOS 303 or concurrent enrollment. Cellular structure and function; membrane biochemistry and transport; cell-cell communication; regulation of cell cycle and apoptosis; cell signaling; cancer biology. Credit not granted for both MBIOS 401 and MBIOS 501. Recommended preparation for graduate students: Introductory genetics and biochemistry coursework. Offered at 400 and 500 level. Typically offered Fall, Spring, and Summer.

402 [M] Genetics Laboratory 3 (1-6) Course Prerequisite: MBIOS 301; MBIOS 304. Basic principles of modern and classical genetics utilizing several species. Typically offered Spring.

404 Molecular Biology 3 Course Prerequisite: MBIOS 301; MBIOS 303; MBIOS 305 or concurrent enrollment. Introduction of prokaryotic and eukaryotic genome organization and gene expression, modern molecular techniques, experimental approaches, genome and gene function and analyses. Typically offered Fall and Summer.

405 Cell Biology of Disease 3 Course Prerequisite: MBIOS 301; MBIOS 303. Discussion of human diseases characterized by cell biological defects, using popular press and research articles as a source of information. Credit not granted for both MBIOS 405 and 505. Offered at 400 and 500 level.

410 Medical Microbiology 3 Course Prerequisite: MBIOS 305; MBIOS 404 or concurrent enrollment. Microbial pathogens and their relationship to disease. Typically offered Spring.

411 [M] Diagnostic Medical Bacteriology 3 (1-6) Course Prerequisite: MBIOS 304; MBIOS 410 or concurrent enrollment. Techniques and tests for the identification of bacteria pathogenic for humans. Typically offered Spring.

413 General Biochemistry 3 Course Prerequisite: MBIOS 303; junior standing. Structure and function of proteins, nucleic acids and biological membranes; principles of enzymology; biochemical methodology. Credit not granted for both MBIOS 413 and MBIOS 513. Recommended preparation: Introductory biochemistry coursework. Offered at 400 and 500 level. Typically offered Fall, Spring, and Summer.

414 General Biochemistry 3 Course Prerequisite: MBIOS 413. Metabolism of carbohydrates, proteins, fats, bioenergetics; photosynthesis; control of metabolic processes. Credit not granted for both MBIOS 414 and MBIOS 514. Offered at 400 and 500 level. Typically offered Spring.

423 Human Genetics 3 Course Prerequisite: MBIOS 301. Exploration of individual and population genetics leading to critical discussion of current social, medical, and scientific issues. Typically offered Spring.

426 Microbial Genetics 3 Course Prerequisite: MBIOS 301; MBIOS 303. Genetics of bacteria, bacteriophages and plasmids; regulation of gene expression; genetic manipulation of microorganisms.

430 [M] Combined Immunology and Virology Laboratory 3 (1-6) Course Prerequisite: MBIOS 304; MBIOS 305; concurrent enrollment MBIOS 440 or 442. Fundamental principles in immunology including the cultivation and characterization of viruses using laboratory techniques. Typically offered Fall.

440 Immunology 3 Course Prerequisite: MBIOS 305. Principles of basic immunology. Credit not granted for both MBIOS 440 and MBIOS 540. Recommended preparation: Introductory microbiology coursework; concurrent enrollment with MBIOS 548 highly recommended. Offered at 400 and 500 level. Typically offered Fall. Cooperative: Open to UI degree-seeking students.

442 General Virology 3 Course Prerequisite: MBIOS 301; MBIOS 303 or concurrent enrollment. The biology of bacterial, animal, and plant viruses. Credit not granted for both MBIOS 442 and MBIOS 542. Recommended preparation: Introductory genetics and biochemistry coursework; concurrent enrollment with MBIOS 548 highly recommended. Offered at 400 and 500 level. Typically offered Spring. Cooperative: Open to UI degree-seeking students.

446 Epidemiology 3 Course Prerequisite: Junior standing. Study of diseases in human populations; concepts of etiology, disease rates, susceptibility and risk factors, screening for disease, and prevention. Typically offered Spring. Cooperative: Open to UI degree-seeking students.

450 Microbial Physiology 3 Course Prerequisite: MBIOS 303; MBIOS 304; MBIOS 305. Basic microbial physiology and its relevance to the processes of applied microbiology. Credit not granted for both MBIOS 450 and 550. Recommended preparation: Introductory genetics, biochemistry or microbiology coursework. Offered at 400 and 500 level. Typically offered Spring.

454 [M] Biochemistry Laboratory 3 (1-6) Course Prerequisite: MBIOS 303; MBIOS 304. Techniques related to the structural and functional analysis of macromolecules including proteins, lipids and carbohydrates. Typically offered Fall.

465 Principles of Biophysical Chemistry 3 Course Prerequisite: MBIOS 303; MATH 140 or 171; PHYSICS 102 or concurrent enrollment, or PHYSICS 202 or concurrent enrollment. Biochemical reactions and processes, molecular recognition, coupled reactions, enzyme catalysis, analysis of macromolecular structure by electrophoresis, sedimentation, viscosity, and spectroscopy. Typically offered Spring.

465 (Effective through Summer 2017) Principles of Biophysical Chemistry 3 Course Prerequisite: MBIOS 303; MATH 140 or 171; PHYSICS 102 or 202. Biochemical reactions and processes, molecular recognition, coupled reactions, enzyme catalysis, analysis of macromolecular structure by electrophoresis, sedimentation, viscosity, and spectroscopy. Typically offered Spring.

478 Bioinformatics 3 (2-3) Course Prerequisite: MBIOS 301, 303, or CPT S 355. Computer analysis of protein and nucleic acid sequences, functional genomics and proteomics data; modeling biological networks and pathways. Credit not granted for both MBIOS 478 and MBIOS 578. Recommended preparation: Introductory genetics or biochemistry coursework. Offered at 400 and 500 level. Typically offered Fall, Spring, and Summer.

490 Special Topics in Molecular Biology V 1-2 May be repeated for credit; cumulative maximum 6 hours. Current topics discussed by experts in the field. Typically offered Spring.

494 [CAPS] [M] Senior Project in Molecular Biosciences 3 Course Prerequisite: Certified major in Biochemistry, Genetics and Cell Biology, or Microbiology; senior standing. Written paper and seminar presentation on laboratory research project. Typically offered Fall and Spring.

495 Internship Training V 1-4 May be repeated for credit; cumulative maximum 8 hours. Course Prerequisite: By permission only. Experience in work related to specific career interests. Typically offered Fall, Spring, and Summer. S, F grading.

498 Directed Research V 1-4 May be repeated for credit. Course Prerequisite: Minimum 1 credit MBIOS 499. Continued laboratory research; requires oral or poster presentation at a WSU event or external meeting. Typically offered Fall, Spring, and Summer.

499 Special Problems V 1-4 May be repeated for credit. Independent study conducted under the jurisdiction of an approving faculty member; may include independent research studies in technical or specialized problems; selection and analysis of specified readings; development of a creative project; or field experiences. Typically offered Fall, Spring, and Summer. S, F grading.

501 Cell Biology 3 Cellular structure and function; membrane biochemistry and transport; cell-cell communication; regulation of cell cycle and apoptosis; cell signaling; cancer biology. Credit not granted for both MBIOS 401 and MBIOS 501. Recommended preparation for graduate students: Introductory genetics and biochemistry coursework. Offered at 400 and 500 level. Typically offered Fall and Spring.

503 Advanced Molecular Biology I 3 DNA replication, gene expression and regulation, including chromatin structure, DNA repair, recombination, genomic editing, and epigenetic regulation. Typically offered Fall.

503 (Effective through Summer 2017) Advanced Molecular Biology I 3 DNA replication and recombination in prokaryotes and eukaryotes; recombinant DNA methods and host/vector systems; genome analysis; transgenic organisms. Recommended preparation: Introductory genetics and biochemistry coursework. Typically offered Fall, Spring, and Summer.

504 (Effective through Summer 2017) Advanced Molecular Biology II 3 Gene expression and regulation in prokaryotes and eukaryotes, including transcription, RNA processing, and translation; chromatin structure; DNA repair. Recommended preparation: Introductory genetics and biochemistry coursework. Typically offered Fall, Spring, and Summer.

505 Cell Biology of Disease 3 Course Prerequisite: MBIOS 301; MBIOS 303. Discussion of human diseases characterized by cell biological defects, using popular press and research articles as a source of information. Credit not granted for both MBIOS 405 and 505. Offered at 400 and 500 level.

507 (Effective through Summer 2017) Critical Analysis of Scientific Literature 2 Course Prerequisite: MBIOS 503; MBIOS 513 or concurrent enrollment. Dissection and discussion of current molecular bioscience papers to foster development of critical reading of primary literature. Typically offered Fall.

508 (Effective through Summer 2017) Quantitative Approaches in Molecular Biosciences 2 Quantitative methods and techniques using examples from the current molecular biosciences primary literature. Recommended preparation: One semester of calculus. Typically offered Even Years - Fall.

513 General Biochemistry 3 Structure and function of proteins, nucleic acids and biological membranes; principles of enzymology; biochemical methodology. Credit not granted for both MBIOS 413 and MBIOS 513. Recommended preparation: Introductory biochemistry coursework. Offered at 400 and 500 level. Typically offered Fall, Spring, and Summer.

514 General Biochemistry 3 Course Prerequisite: MBIOS 513. Metabolism of carbohydrates, proteins, fats, bioenergetics; photosynthesis; control of metabolic processes. Credit not granted for both MBIOS 414 and MBIOS 514. Offered at 400 and 500 level. Typically offered Spring.

525 Advanced Topics in Genetics V 1-3 May be repeated for credit; cumulative maximum 4 hours. Recent genetics research in selected areas. Recommended preparation: MBIOS 503 or an equivalent course providing a basic understanding of molecular biology or molecular genetics. Typically offered Spring.

528 Molecular and Cellular Reproduction 3 (2-2) State of the art concepts of the molecular, cellular, and physiological aspects of mammalian reproduction. (Crosslisted course offered as MBIOS 528, ANIM SCI 558). Typically offered Even Years - Fall. Cooperative: Open to UI degree-seeking students.

529 Selected Topics in Cell Biology V 1-3 May be repeated for credit; cumulative maximum 3 hours. Selected topics in cell biology using current literature. Recommended preparation: MBIOS 401 or an equivalent course providing a basic understanding of a typical eukaryotic cell. Typically offered Spring.

540 Immunology 3 Principles of basic immunology. Credit not granted for both MBIOS 440 and MBIOS 540. Recommended preparation: Introductory microbiology coursework; concurrent enrollment with MBIOS 548 highly recommended. Offered at 400 and 500 level. Typically offered Fall. Cooperative: Open to UI degree-seeking students.

541 Research Seminar 1 May be repeated for credit; cumulative maximum 2 hours. Literature reviews and research reports. Typically offered Fall. S, F grading.

542 General Virology 3 The biology of bacterial, animal, and plant viruses. Credit not granted for both MBIOS 442 and MBIOS 542. Recommended preparation: Introductory genetics and biochemistry coursework; concurrent enrollment with MBIOS 548 highly recommended. Offered at 400 and 500 level. Typically offered Spring. Cooperative: Open to UI degree-seeking students.

548 Selected Topics in Immunology & Virology 1 May be repeated for credit; cumulative maximum 2 hours. Selected topics in immunology and virology using the current literature. Recommended preparation: Concurrent enrollment with MBIOS 540 or 542. Typically offered Fall and Spring. Cooperative: Open to UI degree-seeking students.

549 Seminar in Immunology 1 May be repeated for credit; cumulative maximum 2 hours. Seminar series on advances in immunology. May be repeated for credit; cumulative maximum 2 hours. Recommended preparation: MBIOS 540 or concurrent enrollment. Typically offered Spring.

550 Microbial Physiology 3 Basic microbial physiology and its relevance to the processes of applied microbiology. Credit not granted for both MBIOS 450 and 550. Recommended preparation: Introductory genetics, biochemistry or microbiology coursework. Offered at 400 and 500 level. Typically offered Spring.

561 Biochemical Signaling in Plants, Animals and Microorganisms 3 Course Prerequisite: MBIOS 513. New research on intra and extra cellular biochemical signaling, including communication in plants and hormone action in animals. (Crosslisted course offered as MBIOS 561, MPS 561). Typically offered Spring.

563 Deconstruction of Research 3 Course Prerequisite: Graduate standing in a WSU biomedical based graduate program. Nature and development of scientific investigation through oral and written avenues, and methods of critical analyses applied to questions of biomedical interest. (Crosslisted course offered as NEUROSCI 563, GLANHLTH 563, MBIOS 563, VET MICR 563, VET PATH 563, VET PH 563). Typically offered Fall.

564 Topics in Biomedical Experimentation V 1-3 May be repeated for credit; cumulative maximum 6 hours. Examination of the philosophy of experimental design and practical application and analysis of various experimental approaches in biomedical research. Recommended preparation: graduate standing in a WSU biomedical-based program, and an advanced undergraduate or graduate statistics course. (Crosslisted course offered as NEUROSCI 564, GLANHLTH 564, MBIOS 564, VET MICR 564, VET PATH 564, VET PH 564). Typically offered Fall.

568 Advanced Topics in Molecular Biosciences V 1-3 May be repeated for credit. Recent research in selected areas of molecular biosciences. Typically offered Fall and Spring.

574 Protein Biotechnology 3 Biotechnology related to the isolation, modification and large scale commercial production, patenting and marketing of useful recombinant proteins and products. (Crosslisted course offered as MBIOS 574, CHE 574). Recommended preparation: MBIOS 513. Typically offered Even Years - Spring.

578 Bioinformatics 3 (2-3) Computer analysis of protein and nucleic acid sequences, functional genomics and proteomics data; modeling biological networks and pathways. Credit not granted for both MBIOS 478 and MBIOS 578. Recommended preparation: Introductory genetics or biochemistry coursework. Offered at 400 and 500 level. Typically offered Fall, Spring, and Summer.

579 Molecular Biosciences Seminar 1 May be repeated for credit; cumulative maximum 10 hours. Required of all graduate students in molecular biosciences. Typically offered Fall and Spring. S, F grading.

580 Science Information Literacy 2 Efficient methods to locate and effectively use a wide variety of information resources that will be useful in the work world. Typically offered Fall, Spring, and Summer.

583 Professional Skills Seminar 1 Covers many aspects of professionalism, including professional behavior, professional dress, and professional sensitivity in social settings. Typically offered Fall, Spring, and Summer.

584 Medical Genetics 3 The mechanisms of human heredity and how these mechanisms can influence human health. Typically offered Fall, Spring, and Summer.

585 Molecular Biotechniques 2 Background and application of classical and current techniques involved in cloning, characterization, modification, and expression of genes. Typically offered Summer Session.

586 Molecular Biotechniques Laboratory 1 (0-3) Laboratory exploration of classical and current techniques involved in cloning, characterization, modification, and expression of genes. Recommended preparation: MBIOS 585 or concurrent enrollment. Typically offered Summer Session.

593 Research Proposal 2 May be repeated for credit; cumulative maximum 4 hours. Written proposal and oral defense of research project in the area of molecular biosciences. Typically offered Fall and Spring. S, F grading.

600 Special Projects or Independent Study V 1-18 May be repeated for credit. Independent study, special projects, and/or internships. Students must have graduate degree-seeking status and should check with their major advisor before enrolling in 600 credit, which cannot be used toward the core graded credits required for a graduate degree. Typically offered Fall, Spring, and Summer. S, F grading.

700 Master's Research, Thesis, and/or Examination V 1-18 May be repeated for credit. Independent research and advanced study for students working on their master's research, thesis and/or final examination. Students must have graduate degree-seeking status and should check with their major advisor/committee chair before enrolling for 700 credit. Typically offered Fall, Spring, and Summer. S, U grading.

701 Master's Independent Capstone Project and /or Examination V 1-6 May be repeated for credit. Capstone project or final examination for professional master's degree under the Graduate School. The credits will include a balloted evaluation of the student's completion of the program's capstone/examination requirements by the program's graduate faculty. Students must have graduate degree-seeking status and obtain approval from their major advisor/committee chair before enrolling for 701 credit. S, U grading.

702 Master's Special Problems, Directed Study, and/or Examination V 1-18 May be repeated for credit. Independent research in special problems, directed study, and/or examination credit for students in a non-thesis master's degree program. Students must have graduate degree-seeking status and should check with their major advisor/committee chair before enrolling for 702 credit. Typically offered Fall, Spring, and Summer. S, U grading.

800 Doctoral Research, Dissertation, and/or Examination V 1-18 May be repeated for credit. Course Prerequisite: Admitted to the Molecular Biosciences PhD program. Independent research and advanced study for students working on their doctoral research, dissertation and/or final examination. Students must have graduate degree-seeking status and should check with their major advisor/committee chair before enrolling for 800 credit. Typically offered Fall, Spring, and Summer. S, U grading.

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